Dwarfism – German Shepherd

Nanismus

Code: DWARF

Pituitary dwarfism (also called nanism) is a disease that leads to a dwarf growth of dogs and is caused by degeneration of the pituitary gland with a consequent lack of production of growth hormones.

Dwarfism is an autosomal recessive disease, so the disease affects individuals who receive a mutated gene from both parents.

The disease is caused by a deletion of the 7 bp repeat in intron 5 of the LHX3 gene, in one German Shepherd the insertion of the trinucleotide sequence ACA in exon 5 of the same gene was observed.

GenoCan detects both mutations leading to a dwarfism.

Gene and tested mutations/variants

LHX3, c.622-37-31del, c.545_547dupACA

Často kladené dotazy

German Shepherd

The German Shepherd is a large, agile, muscular dog of noble character and high intelligence. The German Shepherd is a real pleasure for every dog lover. Its defining attribute is character: Loyalty, courage, self-confidence, ability to learn commands for many tasks, and willingness to put his life on the line to defend his loved ones. German Shepherds are gentle family dogs but steadfast guardians.