Exposure to these drugs can lead to severe neurological symptoms such as hypersalivation, ataxia, blindness, tremor, respiratory distress and even death. The cause of the disease is a mutation in the gene that produces P-glycoprotein, whose role is to transport and eliminate certain drugs.
The disease is inherited in an autosomal recessive way, meaning that affected individuals must inherit the mutation in both copies of the gene. However, it is known that even carriers can have a mild adverse reaction after administration of these drugs.
The German Shepherd is a large, agile, muscular dog of noble character and high intelligence. The German Shepherd is a real pleasure for every dog lover. Its defining attribute is character: Loyalty, courage, self-confidence, ability to learn commands for many tasks, and willingness to put his life on the line to defend his loved ones. German Shepherds are gentle family dogs but steadfast guardians.
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