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Chondrodysplasia, chondrodystrophy and degeneration of intervertebral discs – American Cocker Spaniel

Nemoc meziobratlových plotének I. typu

Code: CDPA/CDDY+IVDD
Chondrodysplasia (CDPA) is a genetic disease causing abnormal growth of cartilage and early changes in the structure of growth plates.

The affected dogs are generally characterized by a normal sized trunk and short limbs. Dogs with chondrodysplasia (CDPA) have short legs; this phenotype is characteristic for many breeds such as Welsh Corgi and Dachshund.

Chondrodystrophy (CDDY) is caused by a separate mutation, also includes a short-legged phenotype as well as abnormal premature degeneration of intervertebral discs leading to susceptibility to intervertebral disc herniation (IVDD).

The inheritance of CDDY is semi-dominant (dogs with 2 mutations are smaller than dogs with 1 mutation. However, the inheritance of IVDD is autosomal dominant meaning that 1 mutation is sufficient to express IVDD phenotype.

Genetic testing for these mutations can help breeders to determine if CDDY is present and to identify dogs at risk for IVDD. In breeds where both types of mutations are present, breeders can benefit from test results to implement breeding strategies to reduce incidence of CDDY, while keeping the short-legged phenotype caused by CDPA.

Gene and tested mutations/variants

inzerce FGF4 retrogenu do chr. 18 (CDPA) a chr.12 (CDDY + IVDD)

Často kladené dotazy

American Cocker Spaniel

Big dark eyes, sweet expression, long, lush ears that are so inviting to touch - no wonder that Cocker was for many years the most popular breed in America. Cocker is the AKC's smallest sporting spaniel, growing to about 35-40 centimetres in height. The coat has enough colors and patterns to satisfy any breeder's taste. The balanced body is sturdy and strong, and these fast and durable gundogs move with a graceful and easy gait. They make good playmates for children and are easy to train as companions and sporting dogs. These energetic athletic dogs love playtime and brisk walks.

1490 €

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